Description
NR546 Week 3 Antipsychotic Medications Table
Requirements
Follow these guidelines when completing each component of the assignment. Contact your course faculty if you have questions.
General Instructions
Download Week 3 Medication Table. Open this document with ReadSpeaker docReader and complete the required information using the template.
Include the following sections (detailed criteria listed below and in the grading rubric)
- For each medication listed, complete the following:
- Provide indication, target symptoms, potency, and affected neurotransmitters.
- Include half-life and CYP 450 enzyme information.
- List notable side effects.
- Link notable side effects to the associated pathway or neurotransmitter.
Solution: NR546 Week 3 Antipsychotic Medications Table
This assignment should be submitted to the Week 3 medication table dropbox by sunday at 11:59 p.m. Mt.
| Drug name | Indication
Target symptoms: state if positive or negative effect Potency (if noted. receptor occupancy if noted ) Neurotransmitter(s) affected |
Half-life (T1/2), metabolism (CYP 450 enzyme) | Notable side effects (associate to pathway or NT) |
| Typical antipsychotics (conventional) | |||
| Haloperidol | Acute psychosis, agitation, Tourette’s, schizophrenia
Positive (strong), modest negative High-potency; high D₂ binding → EPS |
14–37 h; hepatic (glucuronidation, CYP3A4 > CYP2D6) | EPS (dystonia, akathisia), NMS, QT prolongation, orthostatic hypotension, weight gain, sedation |
| Thioridazine | Schizophrenia (rare; withdrawn)
Positive > maybe some negative |
21–24 h (variable up to 40 h elderly); CYP2D6 → mesoridazine | Heavy sedation, anticholinergic, hypotension, QTc prolongation, torsades de pointes, retinal changes |
| Thiothixene | Schizophrenia
Positive symptoms |
4–24 h (variable)
CYP1A2 involved |
EPS, sedation, anticholinergic (dry mouth), hypotension, GI upset, vivid dreams |
| Fluphenazine | Schizophrenia maintenance, depot use
Positive > negative |
Oral/IM: ~15 h; depot: 7–10 days; CYP2D6 metabolism | EPS, NMS, sedation, weight gain, prolactin elevation, QTc prolongation, low WBC/LFTs |
| Mesoridazine | Schizophrenia (rare; metabolite of thioridazine)
Positive symptoms |
24–48 h; hepatic/renal; CYP2D6/3A4 mediated | Similar to thioridazine: sedation, hypotension, anticholinergic, QTc risk, arrhythmia |
| Chlorpromazine | Psychosis, agitation, nausea, hiccups
Moderate positive, little negative |
~30 h (range 8–60 h); CYP2D6 metabolism | Sedation, orthostatic hypotension, anticholinergic, photosensitivity, contact dermatitis, weight gain, QTc prolongation, EPS possible |
| Atypical antipsychotics (2nd generation) | |||
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